We have lot of methods for Prevent the USB Pen drive in our network; I have been using this below method for Denying or Allowing some users for pen drive access in my network.
USB Storage drive will work based on these drivers
%SYSTEMROOT%\INF\USBSTORE.INF
%SYSTEMROOT%\INF\USBSTORE.PNF
So I have given rights to access this files using Group Policy
From the Group Policy
Computer Configuration
Windows Settings
Security Settings
File Systems
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Create two Security Group
Like
USB Allow & USB Denny
Prevent the USB driver files for USB Denny group.
Allow USB driver files for USB Allow group.